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Kopets R, Kuibida I, Chernyavska I, et al

BBB blood-brain-barrier HGF hepatocyte growth factor neurotrophic factors are large proteins that lack significant BBB penetrability

The durable result shows up between months three and six, which is also why we book the follow-up photo at week 12 and the second compare at week 24

doi: 10.1186/s12885-023-11519-5 66 YangWLiuLWeiYFangCLiuSZhouFet al

upon binding to TGF1, it recruits TGFBR1 and induces its phosphorylation, thereby activating downstream canonical (SMAD-dependent) and non-canonical (non-SMAD-dependent) intracellular signaling cascades