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44 Moreover, hyperglycemia-induced oxidative stress, AGEs, and chronic inflammation drive glomerular cell senescence through glycogen synthase kinase 3 (GSK3)-modulated nuclear factor erythroid 2-related factor 2 (Nrf2) signaling, impairing repair and worsening inflammation and fibrosis

Once reconstituted, the liquid solution is sensitive to thermal degradation and must be continuously refrigerated at 4C

Oladipo, E

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Treatment should only be continued if there has been a beneficial metabolic response, defined as a reduction in HbA1c of at least 11 mmol/mol (1.0%) and weight loss of at least 3% of initial body weight