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Its primary actions include: Inhibiting the reuptake of dopamine and noradrenaline in the central nervous system Minimal effect on serotonin pathways, distinguishing it from most other antidepressants Potential appetite suppression as a secondary effect, though this is not its primary indication Reducing nicotine cravings through dopaminergic pathways Bupropion is metabolised primarily in the liver by the CYP2B6 enzyme system, producing active metabolites

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Buse JB, Henry RR, Han J, et al, for the Exenatide-113 Study Group

In some cases, significant weight loss and energy deficit can lead to functional hypothalamic amenorrhoea, where the brain temporarily reduces signals to the ovaries

Mayo Clinic: Frequently Asked Questions About Compounded Medications UCLA Health: GLP-1 Microdosing Is Experimental and Unauthorized U.S