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The bioavailability of flavonoids is limited, as only a small fraction (i.e., less than 10% of the ingested quantity) can attain peak concentrations in the bloodstream within a few hours The bioavailability of flavonoids may be subject to various factors, such as ingestion of dietary fiber, macro and micronutrients, the duration of GI transit times, and composition of the gut microbiota (176, 177)

OxS has been proposed as one of the major contributing factors in the destruction of the GI tract, and this is associated with some of the characteristic features of CD, e.g

If you have a sensitive stomach, taking supplements in the evening may also be more comfortable

5-HT2A and 5-HT2C/2B receptor subtypes modulate dopamine release induced in vivo by amphetamine and morphine in both the rat nucleus accumbens and striatum

DOI: 10.1056/NEJMoa2502081 Davies MJ, Bajaj HS, Broholm C, Christiansen E, Fink LN, Hussein Z, et al