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This work defines a carnitine-facilitated route to produce nuclear-cytosolic acetyl-CoA, shedding light on the intricate regulation and compartmentalization of acetyl-CoA metabolism INTRODUCTION Acetyl-CoA is a central metabolic intermediate that is generated during nutrient catabolism, used as a building block for lipid synthesis, and serves as the substrate for protein and metabolite acetylation

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Data are presented as mean standard error of the mean (SEM)