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This effect is highly similar to the ScGrx7 mutants K105A and K105Y (Figs 2 and 3)

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Schiavoni, G., Lucente, M., Di Folca, A., Alessandri, N., Mongiardo, R., and Manzoli, U

Furthermore, gene-editing therapies targeting Angiopoietin-like 3 (ANGPTL3) 399,400 and LDLR 401,402 have entered the preclinical stage, highlighting the broader potential of gene-editing-based lipid-lowering strategies, and long-acting therapies that provide stable and durable lipid-lowering effects could further reduce the risk of cardiovascular events