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As obesity and related illnesses are becoming increasingly common, NAFLD is spreading throughout Eastern nations (Frank et al., 2021)

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Furthermore, protease-activated receptor 2 (PAR2) signaling in melanocytes amplifies oxidative and inflammatory responses through the Akt/NF-B axis, elevating cytokine production and reducing antioxidant defenses, based on CAT and SOD activity, exacerbating skin inflammation 126