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The worsening of symptoms, or the emergence of new symptoms following exertion, provides a valuable opportunity to investigate the underlying metabolic dysfunction associated with these conditions

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Fan H, Gong N, Li TF, Ma AN, Wu XY, Wang MW et al (2015) The non-peptide GLP-1 receptor agonist WB4-24 blocks inflammatory nociception by stimulating -endorphin release from spinal microglia

Additionally, combined with metformin, medication such as Topiramate, Zonisamide, and Valproic Acid may increase the risk of lactic acidosis

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