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The researchers also noted that 23.5% (95% CI, 22.3-24.8) of people meeting FDA indications for tirzepatide reported using medications that may slow gastrointestinal motility, which could increase gastrointestinal adverse effects when combined with any GLP-1 receptor agonist

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For Weight Management Certain treatments can help with weight, as they are approved for chronic weight management in individuals who are overweight

This condition greatly ups their risk of heart disease, type 2 diabetes, stroke and more

This effect is also observed after specific activation of GLP-1R in the NAc and most likely those receptors located on medium spiny neurons that express the dopamine-D1 receptors or dopamine-D2 receptors (Zhang et al., 2020)