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*Correspondence: Yuki Oe, [email protected] ORCID: Yuki Oe, orcid.org/0000-0002-4947-5395 Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Since cardiovascular benefits had been demonstrated previously for liraglutide, dulaglutide and injectable semaglutide, it would not have been ethical to enrol people with type 2 diabetes and CVD, who are at high risk of further cardiovascular events, into a long-term study in which 50% would receive placebo