Ro 31-8220 Size:Solid 10 mg 1-(3-chloro-4-methylbenzoyl)-4-(4-nitrophenyl)piperazine

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Ro 31-8220 Size:Solid 10 mg 1-(3-chloro-4-methylbenzoyl)-4-(4-nitrophenyl)piperazineRo 31 8220 is a PKC inhibitor, which inhibits stimulated fluid pinocytosis of human PMNs induced by the PKC activators phorbol myristate acetate (PMA, IC50 = 1. 35 x 10( 6) M) or diacylglycerols (OAG, diC8) by 95%. Ro 31 8220 showed the apoptotic effect on HL 60 cells, which was mediated by a well characterized transduction process of apoptotic signals: i. e., mitochondrial cytochrome c efflux and the activation of caspase 3 in the cytosol. Moreover,

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