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La hiptesis tri-agonista parte del trabajo seminal de Matthias Tschp y Richard DiMarchi en el Helmholtz Zentrum Mnchen y la Universidad de Indiana a principios de la dcada de 2010, que demostr en modelos animales que la coactivacin racional GLP-1 + GIP + glucagn superaba a cualquier mono-agonista en prdida ponderal sin descompensar glucemia